Chronic constipation (CC) is characterized by unsatisfactory defecation that results from infrequent stools, difficult stool passage, or both. The pathophysiology of CC is multifactorial and may include dysfunction of intestinal motility, visceral sensitivity, ano-rectal musculature and the enteric nervous system1.


Available evidence indicates that self-reported constipation is associated with decreased quality of life1. Constipation most commonly occurs when waste or stool moves too slowly through the digestive tract or cannot be eliminated effectively from the rectum, which may cause the stool to become hard and dry. Chronic constipation has many possible causes2.

Factors that may increase your risk of chronic constipation include:

o   Sex – women are effected most

o   dehydration

o   Eating a diet that's low in fiber

o   Getting little or no physical activity

o   Taking certain medications, including sedatives, narcotics, some antidepressants or medications to lower blood pressure

o   Having a mental health condition such as depression or an eating disorder


If you suffer from constipation, you may qualify for a research study assessing the safety and efficacy of an investigational treatment for this condition.

Qualified participants will be compensated for time and travel. Study medications and study related care are provided at no cost, without the need for health insurance.


Help us advance medical science and find new treatments for constipation. Help us ease the pain experienced by those suffering with this condition. Take a moment to volunteer by completing the form below.

Clinical Trials

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Other paid studies